Closing the loop: 3C versus DNA FISH

@inproceedings{Giorgetti2016ClosingTL,
  title={Closing the loop: 3C versus DNA FISH},
  author={Luca Giorgetti and Edith Heard},
  booktitle={Genome Biology},
  year={2016}
}
Chromosome conformation capture (3C)-based techniques have revolutionized the field of nuclear organization, partly replacing DNA FISH as the method of choice for studying three-dimensional chromosome architecture. Although DNA FISH is commonly used for confirming 3C-based findings, the two techniques are conceptually and technically different and comparing their results is not trivial. Here, we discuss both 3C-based techniques and DNA FISH approaches to highlight their similarities and… CONTINUE READING
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A decade of 3C technologies: insights into nuclear organization

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