Closing the gaps in kinetoplast DNA network replication.


T rypanosomatids are protozoan parasites responsible for important tropical diseases. One example, Trypanosoma brucei, causes African sleeping sickness, and related parasites cause Chagas disease and leishmaniasis. Because they are among the earliest-branching eukaryotes, trypanosomatids have unusual biological properties. One of their most curious features… (More)


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