Closing the gaps among a web of DNA repair disorders.


As recently as six years ago, three human diseases with similar phenotypes were mistakenly believed to be caused by a single genetic defect. The three diseases, Ataxia-telangiectasia, Nijmegen breakage syndrome, and an AT-like disorder are now known, however, to have defects in three separate genes: ATM, NBS1, and MRE11. Furthermore, new recent studies have… (More)


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@article{Michelson2000ClosingTG, title={Closing the gaps among a web of DNA repair disorders.}, author={Rhett J. Michelson and Ted A. Weinert}, journal={BioEssays : news and reviews in molecular, cellular and developmental biology}, year={2000}, volume={22 11}, pages={966-9} }