Closing in on the biological functions of fps/fes and fer

@article{Greer2002ClosingIO,
  title={Closing in on the biological functions of fps/fes and fer},
  author={Peter A. Greer},
  journal={Nature Reviews Molecular Cell Biology},
  year={2002},
  volume={3},
  pages={278-289}
}
  • P. Greer
  • Published 1 April 2002
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family. Recent studies indicate that these kinases have roles in regulating cytoskeletal rearrangements and inside–out signalling that accompany receptor–ligand, cell–matrix and cell–cell interactions. Genetic analysis using transgenic mouse models also implicates these kinases in the regulation of inflammation and innate immunity. 
Fps/Fes and Fer protein-tyrosinekinases play redundant roles in regulating hematopoiesis.
TLDR
Mice lacking both Fps and Fer kinase activities develop normally, show reduced fertility, and display defects in hematopoiesis, thus providing evidence for functional redundancy between Fpsand Fer kinases in regulating hematopoliesis. Expand
FES/FER kinase signaling in hematopoietic cells and leukemias.
  • A. Craig
  • Chemistry, Medicine
  • Frontiers in bioscience
  • 2012
TLDR
With further definition of their roles in immune cells and their progenitors, FES/FER may emerge as relevant therapeutic targets in inflammatory diseases and leukemias. Expand
Structure and regulation of the c-Fes protein-tyrosine kinase.
TLDR
The c-Fes protein-tyrosine kinase is the normal cellular ortholog of several avian and feline retroviral oncoproteins and has been implicated in normal cellular growth regulation, the innate immune response, and tumorigenesis. Expand
Setting the F-BAR: Functions and regulation of the F-BAR protein family
TLDR
Emerging functional information regarding the recently recognized F-BAR domain family and the regulatory mechanisms whereby F- BAR proteins are deployed in diverse processes are reviewed. Expand
Fer Kinase/FerT and Adherens Junction Dynamics in the Testis: An In Vitro and In Vivo Study1
TLDR
Fer kinase structurally associates with the N-cadherin/catenin protein complex in the testis and can possibly be used to mediate signaling function via the cadherin-based cell-cell AJ structures. Expand
The Fer tyrosine kinase regulates an axon retraction response to Semaphorin 3A in dorsal root ganglion neurons
TLDR
Fer plays a more prominent role than Fps/Fes in regulating the axon retraction response to Sema3A in DRG neurons in response to semaphorin 3A, suggesting important roles in developmental or regenerative axon pathfinding through signaling from Sema 3A to the microtubule cytoskeleton. Expand
Activated Fps/Fes tyrosine kinase regulates erythroid differentiation and survival.
TLDR
Data support a role for Fps/Fes in regulating the survival and differentiation of erythroid cells through modulation of Stat5A/B and Erk kinase pathways induced by EPO and SCF. Expand
Fer kinase regulates cell migration through α-dystroglycan glycosylation
This is the first report on the role of Fer kinase in down-regulating the expression of laminin-binding glycans that suppress cell migration. The data show a novel biochemical interaction betweenExpand
The Fps/Fes kinase regulates leucocyte recruitment and extravasation during inflammation
TLDR
A role for Fps in the regulation of leucocyte recruitment to areas of inflammation is shown for the first time, and evidence that the Fps/Fes kinase plays an important role in the innate immune response is provided. Expand
Role of the non-receptor tyrosine kinase fes in cancer.
TLDR
The knowledge of the three dimensional structure of this protein has informed drug design, while at the same time it has helped to shed some light on the molecular mechanism at the basis of kinase activation and functions. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 123 REFERENCES
The c-Fes family of protein-tyrosine kinases.
TLDR
This review highlights the unique aspects of Fes structure, regulation, and function that set it apart from other tyrosine kinase families. Expand
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton
TLDR
CIP4 is a downstream target of activated GTP-bound CDC42, and is similar in sequence to proteins involved in signalling and cytoskeletal control, suggesting that CIP4 may act as a link between Cdc42 signalling and regulation of the actin cytoskeleton. Expand
Analysis of Fes Kinase Activity in Myeloid Cell Growth and Differentiation
TLDR
Proliferative responses to GM‐ CSF and interleukin 3, and the induction of differentiation by G‐CSF were not altered by expression of the kinase mutant Fes protein, indicating that Fes kinase activity is not critical for these biological events in these cell lines. Expand
Nuclear and cytoplasmic location of the FER tyrosine kinase.
TLDR
The location of the FER protein within the cell was investigated by using subcellular fractionation and immunofluorescence and indicates that it may be involved in key regulatory processes. Expand
Regulation of Rho GTPases by p120-catenin.
Three recent reports indicate that p120-catenin can modulate the activities of RhoA, Rac and Cdc42, suggesting an elegant and previously unexpected mechanism for regulating the balance betweenExpand
The Fps/Fes protein-tyrosine kinase promotes angiogenesis in transgenic mice.
TLDR
Results indicate that fps/fes expression is intrinsic to cells of the vascular endothelial lineage and suggest a direct role of the Fps/Fes protein-tyrosine kinase in the regulation of angiogenesis. Expand
The Fes Protein-Tyrosine Kinase Phosphorylates a Subset of Macrophage Proteins That Are Involved in Cell Adhesion and Cell-Cell Signaling*
TLDR
One of the macrophage substrates of Fes is identified as the crk-associated substrate (Cas) and a second substrate as a 130-kDa protein that has been previously described as a T cell activation-dependent substrate and is unrelated to Cas is identified. Expand
A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.
TLDR
It is concluded that the SH2 domain directs the interaction of the P130gag-fps catalytic domain with cellular proteins such as substrates for phosphorylation or regulators of kinase activity important for its transforming ability. Expand
Specific and redundant roles of Src and Fyn in organizing the cytoskeleton
MOUSE embryos lacking Csk, a negative regulator of Src family kinases, exhibit defects in neurulation and die at mid-gestation1,2. To determine the role of activated Src family kinases in the cská¤-Expand
The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.
  • L. Kim, T. Wong
  • Medicine, Biology
  • Molecular and cellular biology
  • 1995
TLDR
The identification of a coiled coil sequence in the FER kinase and the demonstration that the sequence mediates association with a potential substrate suggest a novel mechanism for signal transduction by cytoplasmic tyrosine kinases. Expand
...
1
2
3
4
5
...