Closing a gap in the nuclear envelope.

  title={Closing a gap in the nuclear envelope.},
  author={Marina Vietri and Harald Stenmark and Coen Campsteijn},
  journal={Current opinion in cell biology},
The nuclear envelope (NE) ensures nucleo-cytoplasmic compartmentalization, with trafficking of macromolecules across this double membrane controlled by embedded nuclear pore complexes (NPCs). The NE and associated proteins are dismantled during open mitosis and reestablishment of this barrier during mitotic exit requires dynamic remodeling of endoplasmic reticulum (ER) membranes and coordination with NPC reformation, with NPC deposition continuing during subsequent interphase. In this review… CONTINUE READING
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