Closest known relatives of virus behind COVID-19 found in Laos.

  title={Closest known relatives of virus behind COVID-19 found in Laos.},
  author={Smriti Mallapaty},
Passive Immunotherapy Against SARS-CoV-2: From Plasma-Based Therapy to Single Potent Antibodies in the Race to Stay Ahead of the Variants
The recent rise and dominance of the Omicron family of variants, including the rather disparate BA.1 and BA.2 variants, demonstrate the need to continue to find new approaches to neutralize the rapidly evolving SARS-CoV-2 virus.
Spatial epidemiology and genetic diversity of SARS-CoV-2 and related coronaviruses in domestic and wild animals
The spatial epidemiology, genetic diversity, and statistically significant genetic similarity along with per-gene recombination events of SARS-CoV-2 and related viruses (SC2r-CoVs) in animals globally are understood and vaccine provision for pet and zoo animals is recommended to reduce the chance of transmission.
Transmission dynamics and susceptibility patterns of SARS‐CoV‐2 in domestic, farmed and wild animals: Sustainable One Health surveillance for conservation and public health to prevent future epidemics and pandemics
The founding of SARS‐CoV‐2 in wild animal reservoirs can confront the control of the virus in humans and might carry a risk to the welfare and conservation of wildlife as well, and it is suggested vaccinating pets and captive animals to stop spillovers and spillback events.
SARS-CoV-2 and MERS-CoV Share the Furin Site CGG-CGG Genetic Footprint
Light is shed on recombination as origin of the virus CGG-CGG arginine dimer in the S1/S2 cleavage site, which is highly unlikely to find in betacoronavirus wildlife, but it is there.


A comprehensive survey of bat sarbecoviruses across China for the origin tracing of SARS-CoV and SARS-CoV-2
The first systematic survey of bat CoV in China during the outbreak of Corona Virus Disease 2019 revealed the presence of a general geographical distribution pattern for bat sarbecoviruses, with the highest genetic diversity and sequence homology to SARS-CoV or SARV-2 along the southwest border of China, the least in the northwest of China.
Coronaviruses with a SARS-CoV-2-like receptor-binding domain allowing ACE2-mediated entry into human cells isolated from bats of Indochinese peninsula
It is shown that bat-borne SARS-CoV-2-like viruses potentially infectious for humans circulate in Rhinolophus spp.
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia
Molecular and serological evidence of SARS-CoV-2 related coronaviruses (SC2r-CoVs) actively circulating in bats in Southeast Asia are reported and the geographic distribution of genetically diverse SC2r -CoVs from Japan and China to Thailand over a 4800-km range is extended.
A novel SARS-CoV-2 related coronavirus in bats from Cambodia
The identification of SARS-CoV-2 related coronaviruses in two Rhinolophus shameli bats sampled in Cambodia in 2010 is described and suggests that Southeast Asia represents a key area to consider in the ongoing search for the origins of Sars-Cov-2, and in future surveillance for coronavIRuses.
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
Estimates are obtained from three approaches that the most likely divergence date of SARS-CoV-2 from its most closely related available bat sequences ranges from 1948 to 1982, indicating that there are high levels of co-infection in horseshoe bats and that the viral pool can generate novel allele combinations and substantial genetic diversity.
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China, and it is shown that this virus belongs to the species of SARSr-CoV, indicates that the virus is related to a bat coronav virus.
Preprint at Research Square 871965/v1 (2021)
  • 2021
Preprint at bioRxiv (2021)
  • 2021