Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.

@article{Schnberg2006CloselyRC,
  title={Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1.},
  author={Svanhild Arentz Sch\onberg and Anne G\oril Lundemo and Torill Fladvad and Kristin Holmgren and Hilde Bremseth and Asbj\orn Magne Nilsen and Odrun Arna Gederaas and K{\aa}re E Tvedt and Kjartan Wollo Egeberg and Hans Einar Krokan},
  journal={The FEBS journal},
  year={2006},
  volume={273 12},
  pages={2749-65}
}
N-6 polyunsaturated fatty acids (PUFAs) may be associated with increased risk of colon cancer, whereas n-3 PUFAs may have a protective effect. We examined the effects of docosahexaenoic acid (DHA), eicosapentaenoic acid and arachidonic acid on the colon carcinoma cell lines SW480 derived from a primary tumour, and SW620 derived from a metastasis of the same tumour. DHA had the strongest growth-inhibitory effect on both cell lines. SW620 was relatively more growth-inhibited than SW480, but SW620… CONTINUE READING
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