Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration.

@article{Shi2002ClosedSC,
  title={Closed site complexes of adenine phosphoribosyltransferase from Giardia lamblia reveal a mechanism of ribosyl migration.},
  author={Wuxian Shi and Anne E Sarver and Ching C. Wang and Kelly S E Tanaka and Steven C. Almo and Vern L Schramm},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 42},
  pages={39981-8}
}
The adenine phosphoribosyltransferase (APRTase) from Giardia lamblia was co-crystallized with 9-deazaadenine and sulfate or with 9-deazaadenine and Mg-phosphoribosylpyrophosphate. The complexes were solved and refined to 1.85 and 1.95 A resolution. Giardia APRTase is a symmetric homodimer with the monomers built around Rossman fold cores, an element common to all known purine phosphoribosyltransferases. The catalytic sites are capped with a small hood domain that is unique to the APRTases… CONTINUE READING

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