Corpus ID: 237490343

Closed-loop targeted optogenetic stimulation of C. elegans populations

  title={Closed-loop targeted optogenetic stimulation of C. elegans populations},
  author={Mochi Liu and Sandeep Kumar and Anuj K Sharma and Andrew Michael Leifer},
We present a high-throughput optogenetic illumination system capable of simultaneous closed-loop light delivery to specified targets in populations of moving Caenorhabditis elegans. The instrument addresses three technical challenges: it delivers targeted illumination to specified regions of the animal’s body such as its head or tail; it automatically delivers stimuli triggered upon the animal’s behavior; and it achieves high throughput by targeting many animals simultaneously. The instrument… Expand


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