Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish

@inproceedings{Pineda2013ClosedloopNS,
  title={Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish},
  author={Ricardo Pineda and Christine Elizabeth Beattie and Charles W. Hall},
  booktitle={Disease models & mechanisms},
  year={2013}
}
Neural stimulation can reduce the frequency of seizures in persons with epilepsy, but rates of seizure-free outcome are low. Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex. Cortical norepinephrine then increases GABAergic transmission and increases seizure threshold. Another approach, responsive nervous stimulation, prevents seizures by reactively shocking the seizure onset zone in precise synchrony with seizure… CONTINUE READING

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