Closed-Loop and Activity-Guided Optogenetic Control

@article{Grosenick2015ClosedLoopAA,
  title={Closed-Loop and Activity-Guided Optogenetic Control},
  author={Logan Grosenick and James H. Marshel and Karl Deisseroth},
  journal={Neuron},
  year={2015},
  volume={86},
  pages={106-139}
}
Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In particular, observing and feeding back the effects of circuit interventions on physiologically relevant… CONTINUE READING
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