Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness

@article{Hadjipanayi2009CloseDO,
  title={Close dependence of fibroblast proliferation on collagen scaffold matrix stiffness},
  author={E. Hadjipanayi and V. Mudera and R. A. Brown},
  journal={Journal of Tissue Engineering and Regenerative Medicine},
  year={2009},
  volume={3}
}
  • E. Hadjipanayi, V. Mudera, R. A. Brown
  • Published 2009
  • Chemistry, Medicine
  • Journal of Tissue Engineering and Regenerative Medicine
Human dermal fibroblasts (HDFs) in free‐floating collagen matrices show minimal proliferation, although this may increase when the matrix is ‘under tension’. We have investigated the detailed mechanics underlying one of the possible controls of this important cell behaviour, in particular the hypothesis that this is a response to substrate stiffness. Hyperhydrated collagen gels were plastic‐compressed (PC) to give a predetermined collagen density and stiffness. Mechanical properties were tested… Expand
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Fibroblast Quiescence in Floating or Released Collagen Matrices
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