Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats.

@article{Squadrito1992CloricromeneAC,
  title={Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in rats.},
  author={Francesco Squadrito and Domenica Altavilla and Giuseppe Maurizio Campo and Gioacchino Calapai and Mariapatrizia Ioculano and Basilia Zingarelli and Antonino Saitta and Marco Prosdocimi and Achille Patrizio Caputi},
  journal={European journal of pharmacology},
  year={1992},
  volume={210 2},
  pages={107-13}
}
Endotoxin shock was induced in male rats by an intravenous (i.v.) injection of Salmonella enteriditis lipopolysaccharide (LPS; 20 mg/kg i.v.). Survival rate, macrophage and serum tumor necrosis factor (TNF-alpha), mean arterial blood pressure (MAP) and white blood cell count were then evaluated. Furthermore the in vitro effect of cloricromene on peritoneal macrophage phagocytosis and TNF-alpha release by primed peritoneal macrophages was investigated. LPS administration caused animal death (0… CONTINUE READING