Clorgyline. A new treatment for patients with refractory rapid-cycling disorder.

@article{Potter1982ClorgylineAN,
  title={Clorgyline. A new treatment for patients with refractory rapid-cycling disorder.},
  author={William Z. Potter and Dennis L. Murphy and Thomas A. Wehr and Markku Linnoila and Frederick K. Goodwin},
  journal={Archives of general psychiatry},
  year={1982},
  volume={39 5},
  pages={505-10}
}
Five women with primary, major, bipolar affective disorder, characterized by rapid mood cycles and nonresponsiveness to conventional drug treatments, including lithium carbonate, were given low doses (2.5 to 10.0 mg/24 hr) of clorgyline, a selective inhibitor of monoamine oxidase type A. In four patients, clorgyline, along or in combination with lithium carbonate, prolonged the duration and lessened the severity of mood cycles. One patient experienced prolonged mania while receiving clorgyline… CONTINUE READING