Clopidogrel with or without omeprazole in coronary artery disease.

  title={Clopidogrel with or without omeprazole in coronary artery disease.},
  author={Deepak L Bhatt and Byron L. Cryer and Charles F. Contant and M Cohen and A. Iriarte Lanas and Thomas J. Schnitzer and Thomas L. Shook and Pablo Lapuerta and Mark A Goldsmith and L Laine and Benjamin M. Scirica and Sabina A. Murphy and Christopher Paul Cannon},
  journal={The New England journal of medicine},
  volume={363 20},
BACKGROUND Gastrointestinal complications are an important problem of antithrombotic therapy. Proton-pump inhibitors (PPIs) are believed to decrease the risk of such complications, though no randomized trial has proved this in patients receiving dual antiplatelet therapy. Recently, concerns have been raised about the potential for PPIs to blunt the efficacy of clopidogrel. METHODS We randomly assigned patients with an indication for dual antiplatelet therapy to receive clopidogrel in… CONTINUE READING
Highly Influential
This paper has highly influenced 18 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
363 Citations
39 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 363 extracted citations


Publications referenced by this paper.
Showing 1-10 of 39 references

Association of cytochrome P 450 2 C 19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel ther

  • AR Shuldiner, O’Connell, KP Bliden
  • JAMA
  • 2009

Similar Papers

Loading similar papers…