Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.

@article{Wong2009ClopidogrelVP,
  title={Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.},
  author={Pancras C. Wong and Earl J. Crain and Carol A. Watson and Ji Hua and William A. Schumacher and Robert P. Rehfuss},
  journal={Thrombosis and haemostasis},
  year={2009},
  volume={101 1},
  pages={108-15}
}
The new P2Y(12) antagonist prasugrel produces greater inhibition of ADP-induced platelet aggregation (IPA) and reduction of thrombotic events in patients versus approved doses of clopidogrel, but increases major bleeding. We examined whether IPA level or P2Y(12) receptor occupancy (RO) could be optimized to better balance the efficacy and bleeding effects of these thienopyridines and reduce the response variability in rabbits. Rabbits were given three daily oral doses of clopidogrel (0.3-30 mg… CONTINUE READING