Clopidogrel variability: role of plasma protein binding alterations.

  title={Clopidogrel variability: role of plasma protein binding alterations.},
  author={Shobana Ganesan and Craig Williams and Cheryl L Maslen and Ganesh Cherala},
  journal={British journal of clinical pharmacology},
  volume={75 6},
AIM The large inter-individual variability in clopidogrel response is attributed to pharmacokinetics. Although, it has been used since the late 1990s the pharmacokinetic fate of clopidogrel and its metabolites are poorly explained. The variable response to clopidogrel is believed to be multi-factorial, caused both by genetic and non-genetic factors. In this study, we examined whether the inactive metabolite can alter the plasma protein binding of the active metabolite, thus explaining the large… CONTINUE READING