Clopidogrel pharmacogenetics and its clinical implications.

  title={Clopidogrel pharmacogenetics and its clinical implications.},
  author={Mukesh Bikram Singh and Bipin Thapa and Rohit Romesh Arora},
  journal={American journal of therapeutics},
  volume={17 3},
Pharmacogenetics encompasses a range of phenomena ranging from pharmacology to therapeutics to toxicology and generally focuses on the study of genetic factors related to interindividual variability in drug response. Individual differences in the rate of platelet reactivity markedly influence normal hemostasis and the pathologic outcome of thrombosis. Response to clopidogrel varies widely, with nonresponse rates in various studies ranging from 4%-30% at 24 hours. Polymorphism involved in the… CONTINUE READING


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