Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome.

@article{Xiao2004ClopidogrelIP,
  title={Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome.},
  author={Zihui Xiao and Pierre Th{\'e}roux},
  journal={Journal of the American College of Cardiology},
  year={2004},
  volume={43 11},
  pages={1982-8}
}
OBJECTIVES We sought to characterize the effects of clopidogrel on the activation of circulating platelets, the activation and aggregation of ex vivo platelets, and the interactions with leukocytes in patients with a non-ST-segment elevation in acute coronary syndromes (ACS). BACKGROUND The significant benefits of clopidogrel in cardiovascular trials suggest that blockage of the P2Y(12) receptor may be associated with important biologic consequences. METHODS Blood samples obtained from 23… CONTINUE READING