Clopidogrel-drug interactions.

@article{Bates2011ClopidogreldrugI,
  title={Clopidogrel-drug interactions.},
  author={Eric R. Bates and Wei C. Lau and Dominick Joseph Angiolillo},
  journal={Journal of the American College of Cardiology},
  year={2011},
  volume={57 11},
  pages={
          1251-63
        }
}
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184 Citations
Highly Influential Citations
9
Background Citations
72
Methods Citations
5
Results Citations
2

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184 Citations

Clopidogrel Interactions: Consider while prescribing
TLDR
The clopidogrel is commonly prescribed in many serious disorders such as cardiovascular, hypercholesteraemia and lack of information or uncertainty may cost serious outcomes.
Drug-drug interactions between clopidogrel and novel cardiovascular drugs.
Clopidogrel drug interactions: a review of the evidence and clinical implications
TLDR
Most studies assessing the clinical implications of clopidogrel–drug interactions have not shown to significantly affect outcomes, however, awareness of these DDIs remains important for optimizing the selection of concomitant therapies.
Pharmacology and Factors Affecting the Therapeutic Efficacy of Clopidogrel
TLDR
The purpose of this review is to discuss the contribution of individual factors responsible for variations of action and clopidogrel efficacy, which will be very useful for physicians, pharmacists, and healthcare personnel for considering and increasing the safety and efficacy of clopIDogrel therapy.
Genetics of platelet inhibitor treatment.
TLDR
Loss-of-function polymorphisms in CYP2C19 are the strongest individual variables affecting pharmacokinetics and antiplatelet response to clopidogrel, but explain no more than 5 to 12% of the variability in adenosine diphosphate-induced platelet aggregation on clopIDogrel.
Amlodipine – not a significant contributor to clopidogrel non-response?
TLDR
The finding that carriers of CYP2C19*2 polymorphisms who are treated with clopidogrel after coronary stenting are at increased risk of adverse thrombotic events is examined, as well as the importance of individual CYP450 enzymes in clopIDogrel metabolism to its active form.
High on-treatment platelet reactivity and P2Y12 antagonists in clinical trials.
TLDR
This review will focus on the current status of alternate strategies for more sufficient suppression of high platelet reactivity and the use of other anti-platelet medications or alternative dosing strategies for clopidogrel in patients with reduced effectiveness of clopIDogrel.
Cytochrome P450-mediated cardiovascular drug interactions
  • A. Scheen
  • Biology, Medicine
    Expert opinion on drug metabolism & toxicology
  • 2011
TLDR
Clinicians are encouraged to develop their knowledge of CYP-mediated DDIs so that they can choose safe drug combination regimens, adjust drug dosages appropriately and conduct therapeutic drug monitoring for drugs with narrow therapeutic indices.
Beneficial Pharmacokinetic Drug Interactions
TLDR
An overview of the theoretical rationale for beneficial drug interactions with specific examples of interactions that are currently being used clinically or actively undergoing research is provided.
The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics
TLDR
This review aimed to review the literature on factors associated with the variable platelets reactivity response to clopidogrel, as well as appraising current methods for the personalization of clopIDogrel therapy.
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References

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