Clopidogrel, a P2Y12 Receptor Antagonist, Potentiates the Inflammatory Response in a Rat Model of Peptidoglycan Polysaccharide-Induced Arthritis

@inproceedings{Garcia2011ClopidogrelAP,
  title={Clopidogrel, a P2Y12 Receptor Antagonist, Potentiates the Inflammatory Response in a Rat Model of Peptidoglycan Polysaccharide-Induced Arthritis},
  author={Analia E. Garcia and Sripal Reddy Mada and Mario C. Rico and Raul A. Dela Cadena and Satya P Kunapuli},
  booktitle={PloS one},
  year={2011}
}
The P2Y12 receptor plays a crucial role in the regulation of platelet activation by several agonists, which is irreversibly antagonized by the active metabolite of clopidogrel, a widely used anti-thrombotic drug. In this study, we investigated whether reduction of platelet reactivity leads to reduced inflammatory responses using a rat model of erosive arthritis. We evaluated the effect of clopidogrel on inflammation in Lewis rats in a peptidoglycan polysaccharide (PG-PS)-induced arthritis model… CONTINUE READING
22 Extracted Citations
47 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 22 extracted citations

Referenced Papers

Publications referenced by this paper.
Showing 1-10 of 47 references

and coronary artery disease

  • MC Rico, JM Manns, JB Driban, AB Uknis, SP Kunapuli
  • 2008

Similar Papers

Loading similar papers…