Clonogenic response of cells of murine intestinal crypts to 12 cytotoxic drugs

@article{Moore1985ClonogenicRO,
  title={Clonogenic response of cells of murine intestinal crypts to 12 cytotoxic drugs},
  author={James V. Moore},
  journal={Cancer Chemotherapy and Pharmacology},
  year={1985},
  volume={15},
  pages={11-15}
}
The in situ response of clonogenic cells in murine intestinal crypts to graded doses of 12 clinically used cytotoxic drugs has been measured by the crypt microcolony assay. For the alkylating agents mechlorethamine hydrochloride and BCNU, survival curves down to three logs of crypt depletion could be obtained. However, with isopropyl methane sulphonate only… CONTINUE READING