Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.

@article{Matsui2008ClonogenicMM,
  title={Clonogenic multiple myeloma progenitors, stem cell properties, and drug resistance.},
  author={William Matsui and Qiuju H. Wang and Jamie P. Barber and Sarah Tiffany Brennan and Barbara Desrosier Smith and Ivan Borrello and Ian Mcniece and Lan Lin and Richard Frederick Ambinder and Craig Peacock and D Neil Watkins and Carol Ann Huff and Richard M. Jones},
  journal={Cancer research},
  year={2008},
  volume={68 1},
  pages={
          190-7
        }
}
Many agents are active in multiple myeloma, but the majority of patients relapse. This clinical pattern suggests most cancer cells are eliminated, but cells with the clonogenic potential to mediate tumor regrowth are relatively chemoresistant. Our previous data suggested that CD138(+) multiple myeloma plasma cells cannot undergo long-term proliferation but rather arise from clonogenic CD138(neg) B cells. We compared the relative sensitivity of these distinct cell types to clinical antimyeloma… CONTINUE READING

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