Clonogenic and nonclonogenic in vitro chemosensitivity assays.

  title={Clonogenic and nonclonogenic in vitro chemosensitivity assays.},
  author={Larry M. Weisenthal and Marc E. Lippman},
  journal={Cancer treatment reports},
  volume={69 6},
We need practical laboratory methods for predicting the chemosensitivity of human neoplasms. Over the past 20 years, numerous investigators have implied or stated with increasing certitude that clonogenic assays are the most valid (or only valid) approach to predictive chemosensitivity testing. We feel that this point of view may have insufficient scientific validity and may be harmful to progress in this area. In addition to well-known technical problems, there are serious theoretical problems… CONTINUE READING

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