Cloning the laboratory mouse.

@article{Wakayama1999CloningTL,
  title={Cloning the laboratory mouse.},
  author={Teruhiko Wakayama and Ryuzo Yanagimachi},
  journal={Seminars in cell & developmental biology},
  year={1999},
  volume={10 3},
  pages={
          253-8
        }
}
A brief account is given of early attempts to clone mammals (mice) by transferring cells (nuclei) of preimplantation embryos into enucleated oocytes, zygotes or blastomeres of two-cell embryos. This is followed by a brief review of recent successes using adult somatic cells: mammary gland cells for sheep, muscle cells for cattle and cumulus cells for mice. We have developed a technique for cloning the laboratory mouse by transferring cumulus cell nuclei into enucleated oocytes. With this… CONTINUE READING

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