Cloning of the single strand DNA-binding protein important for maximal expression and thyrotropin (TSH)-induced negative regulation of the TSH receptor.

@article{Ohmori1996CloningOT,
  title={Cloning of the single strand DNA-binding protein important for maximal expression and thyrotropin (TSH)-induced negative regulation of the TSH receptor.},
  author={Masayuki Ohmori and Masaru Ohta and Hiroki Shimura and Y Shimurat and Koichi Suzuki and Leonard D. Kohn},
  journal={Molecular endocrinology},
  year={1996},
  volume={10 11},
  pages={
          1407-24
        }
}
Contiguous with the 5'-end of the thyroid transcription factor-1 (TTF-1) element upstream of the minimal TSH receptor (TSHR) promoter and within it, there is an element on the noncoding strand with single strand- binding activity. Mutation analyses indicate that it is functionally distinct from the TTF-1 element and is important for the constitutive expression and TSH/cAMP-induced negative autoregulation of the TSHR in thyroid cells but only constitutive expression in nonthyroid cells. In this… CONTINUE READING

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