Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.

@article{Li2004CloningOT,
  title={Cloning of the rat beta-catenin gene (Ctnnb1) promoter and its functional analysis compared with the Catnb and CTNNB1 promoters.},
  author={Qingjie Li and W. Mohaiza Dashwood and Xiaoying Zhong and Mohamed B Al-Fageeh and Roderick H Dashwood},
  journal={Genomics},
  year={2004},
  volume={83 2},
  pages={231-42}
}
Considerable recent interest has focused on the stabilization and accumulation of beta-catenin protein in human and animal tumors and the corresponding activation of downstream beta-catenin/TCF/LEF target genes. However, there is only sparse information on the regulation of beta-catenin expression at the transcriptional level and its possible involvement in physiological and pathophysiological processes. We report here the cloning and characterization of a 3.6-kb promoter fragment from the rat… CONTINUE READING

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