Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptor

@article{Lake1994CloningOT,
  title={Cloning of the rat and human prostaglandin F2$\alpha$ receptors and the expression of the rat prostaglandin F2$\alpha$ receptor},
  author={Staffan Lake and Hjalmar Gullberg and J. Wahlqvist and A M Sj{\"o}gren and Anne Kinhult and Peter Thomas Lind and Ewa Hellstr{\"o}m‐Lindahl and Johan Wilhelm Stjernschantz},
  journal={FEBS Letters},
  year={1994},
  volume={355}
}
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67 Citations
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67 Citations

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Molecular Cloning and Characterization of the Human Prostanoid DP Receptor (*)
TLDR
The cloned and expressed a functional cDNA for the hDP receptor showed the highest degree of identity with the hIP and hEP2 receptors, followed by the hEP4 receptor and the rank order of affinities for prostaglandins and prostaglandsin analogs was as predicted for the DP receptor.
Regulation of prostaglandin F2 alpha receptor expression in cultured human granulosa-luteal cells.
PGF2 alpha is a metabolite of arachidonic acid that triggers regression of the corpus luteum. Recent animal studies have indicated that PGF2 alpha (FP) receptor messenger ribonucleic acid (mRNA) is…
Regulation of Prostaglandin F2α Receptor Expression in Cultured Human Granulosa-Luteal Cells1.
PGF2 alpha is a metabolite of arachidonic acid that triggers regression of the corpus luteum. Recent animal studies have indicated that PGF2 alpha (FP) receptor messenger ribonucleic acid (mRNA) is…
Prostaglandin F2α Receptor in the Corpus Luteum: Recent Information on the Gene, Messenger Ribonucleic Acid, and Protein1
TLDR
Moieties of the PGF2α molecule that are essential for binding or specificity of binding to the FPr have been identified by radioreceptor binding studies and key amino acids have been suggested to be critical for binding of FPr to P GF2α based on three-dimensional modeling and comparisons with other G-protein-coupled receptors.
Localization of the prostaglandin F2 alpha receptor in rat tissues.
Expression and regulation of prostaglandin F receptor mRNA in rodent osteoblastic cells.
A novel biological role for prostaglandin D2 is suggested by distribution studies of the rat DP prostanoid receptor.
Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha.
TLDR
The human FP may be activated specifically, by the free radical-catalyzed F2 isoprostane, 12-iso-PGF2alpha, in addition to the cyclooxygenase product, PGF2 alpha, where oxidant stress and augmented prostaglandin biosynthesis coincide.
Regulation of prostaglandin F2α-receptor mRNA in human granulosa-luteal cells by human chorionic gonadotrophin and prostaglandin F2α
TLDR
In the human granulosa luteal cell, PGF2α-R mRNA levels are inversely related to hCG-stimulated steroidogenesis (which was biphasic in nature), thus providing a potential form of negative feedback on its own actions, which may be important in rescuing the corpus luteum from PGF 2α-mediated luteolysis should pregnancy occur.
Localization of the prostaglandin F2 alpha receptor messenger RNA and protein in the cynomolgus monkey eye.
TLDR
The FP receptor was found to be distributed widely in the ocular tissues, suggesting an array of autocrine and paracrine functions of PGF2 alpha in the eye.
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References

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Molecular cloning and expression of a cDNA of the bovine prostaglandin F2 alpha receptor.
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TLDR
Results suggest that this receptor belongs to EP1 subtype of PGE receptor, and Northern blot analysis demonstrated that the mRNA of this receptor is expressed abundantly in kidney and in a lessor amount in lung.
Cloning and expression of a cDNA for the human prostanoid IP receptor.
TLDR
A cDNA clone coding for a functional human prostanoid IP receptor that is functionally coupled to a signaling pathway involving stimulation of intracellular cAMP production is cloned and expressed.
Cloning and expression of a cDNA for mouse prostaglandin E receptor EP2 subtype.
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TLDR
Sequencing, homology and hydrophobicity analyses revealed that the prostanoid receptors constitute a family of receptors of similar structure, and all are rhodopsin-type receptors with putative seven transmembrane domains.
Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells.
TLDR
It is postulated that intracellular cyclic AMP levels in platelets are buffered by a distinct prostaglandin receptor that mediates inhibition of cyclicAMP formation, which is coupled to inhibition of adenylate cyclase in human erythroleukaemia cells.
Cloning and expression of cDNA for a human thromboxane A2 receptor
TLDR
This first report on the molecular structure of an eicosanoid receptor will promote the molecular pharmacology and pathophysiology of these bioactive compounds.
Development and regulation of the prostaglandin F2α receptor in the rat ovary
TLDR
It is suggested that luteal cells are the only cell type of the ovary, which is endowed with specific receptors for PGF2 alpha, and the apparent cyclic variation of prostaglandin receptors must be ascribed to occupancy of the receptors by varying amounts of endogenous prostag landin F2 alpha.
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