Cloning of the proteinase that facilitates infection by schistosome parasites.

@article{Newport1988CloningOT,
  title={Cloning of the proteinase that facilitates infection by schistosome parasites.},
  author={George Newport and James H McKerrow and Richard Hedstrom and Matthew Petitt and L McGarrigle and Priscilla J. Barr and Nina Agabian},
  journal={The Journal of biological chemistry},
  year={1988},
  volume={263 26},
  pages={
          13179-84
        }
}
Four cDNA clones encoding a proteinase which facilitates skin invasion by schistosome parasites were isolated by screening a schistosome sporocyst cDNA library, using an oligonucleotide probe containing sequences complementary to predicted 5'-translated regions of its RNA. The amino acid sequence of the enzyme, as deduced from the DNA sequence of the clones, indicates that the enzyme is a serine protease which in many respects is similar to vertebrate pancreatic elastases, although regions… CONTINUE READING

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