Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle

@article{Guhenneux1997CloningOT,
  title={Cloning of the mouse BTG3 gene and definition of a new gene family (the BTG family) involved in the negative control of the cell cycle},
  author={Fabienne Gu{\'e}henneux and Laurent Duret and M Callanan and R Bouhas and Sandrine Hayette and Cyril Berthet and Christiane Samarut and Ruth Rimokh and A Birot and Qian-fei Wang and J Magaud and JP Rouault},
  journal={Leukemia},
  year={1997},
  volume={11},
  pages={370-375}
}
It is well known that loss of tumor suppressor genes and more generally of antiproliferative genes plays a key role in the development of most tumors. We report here the cloning of the mouse BTG3 gene and show that its human counterpart maps on chromosome 21. This evolutionarily conserved gene codes for a 30 kDa protein and is expressed in most adult murine and human tissues analyzed. However, we demonstrate that its expression is cell cycle dependent and peaks at the end of the G1 phase. This… CONTINUE READING