Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization.

@article{Almendro1996CloningOT,
  title={Cloning of the human platelet endothelial cell adhesion molecule-1 promoter and its tissue-specific expression. Structural and functional characterization.},
  author={Nuria Almendro and Teresa Bell{\'o}n and Carlos Rius and Pedro Lastres and Carmen Langa and A Corb{\'i} and Carmelo Bernabeu},
  journal={Journal of immunology},
  year={1996},
  volume={157 12},
  pages={
          5411-21
        }
}
Platelet endothelial cell adhesion molecule-1 (PECAM-1; CD31) is a cell adhesion molecule involved in transendothelial migration and expressed by hemopoietic and endothelial cells. To understand the mechanisms underlying its regulated expression, a genomic clone containing 1555 bp of the 5'-flanking region and the first exon of the human PECAM-1 gene has been isolated. The 5'-flanking region of the PECAM-1 gene lacks a consensus TATA box, but contains consensus motifs for Sp1, EGR1, ets, helix… CONTINUE READING
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