Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation.

@article{Bascom1993CloningOT,
  title={Cloning of the human and murine ROM1 genes: genomic organization and sequence conservation.},
  author={Roger A. Bascom and Keith Schappert and Roderick R Mcinnes},
  journal={Human molecular genetics},
  year={1993},
  volume={2 4},
  pages={385-91}
}
Rom-1 and peripherin are related membrane proteins of the photoreceptor outer segments. Both proteins are located at the rims of the photoreceptor disks, where they may act jointly in disk biogenesis. Mutations in the gene (RDS) encoding peripherin cause autosomal dominant retinitis pigmentosa, autosomal dominant punctata albescens and butterfly macular degeneration in man, and retinal degeneration slow in mice. To facilitate ROM1 mutation and linkage analysis in inherited retinal diseases, we… CONTINUE READING

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