Cloning of the gp63 surface protease of Leishmania infantum. Differential post-translational modifications correlated with different infective forms.

@article{GonzalezAseguinolaza1997CloningOT,
  title={Cloning of the gp63 surface protease of Leishmania infantum. Differential post-translational modifications correlated with different infective forms.},
  author={Gloria Gonzalez-Aseguinolaza and F. J. Adell Almaz{\'a}n and Jos{\'e} Francisco Rodr{\'i}guez and Alberto Marquet and Vicente Larraga},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1361 1},
  pages={92-102}
}
The Leishmania cell surface virulence factor gp63 is a protease family that plays an important role in the survival of the parasite protozoon into the host macrophages. We have cloned and characterised the gp63 gene from L. infantum. The sequence analysis of the gene indicates the existence of a high degree of conservation with the other old world species L. major and L. donovani. The similarity is lower with new world species with the exception of L. chagasi which shows a strikingly high… CONTINUE READING