Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

@article{Sunahara1991CloningOT,
  title={Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1},
  author={Roger K Sunahara and H P Guan and Brian F O'dowd and Philip Seeman and Lisanne G. Laurier and Gordon Y Ng and Susan R. George and Joeseph Torchia and Hubert H. M. Van Tol and Hyman B. Niznik},
  journal={Nature},
  year={1991},
  volume={350},
  pages={614-619}
}
DOPAMINE receptors belong to a superfamily of receptors that exert their biological effects through guanine nucleotide-binding (G) proteins. Two main dopamine receptor subtypes have been identified, D1 and D2, which differ in their pharmacological and biochemical characteristics. D1 stimulates adenylyl cyclase activity, whereas D2 inhibits it1–3. Both receptors are primary targets for drugs used to treat many psychomotor diseases, including Parkinson's disease and schizophrenia4,5. Whereas the… CONTINUE READING
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