Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1

@article{Sunahara1991CloningOT,
  title={Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1},
  author={R. Sunahara and H. Guan and B. O'dowd and P. Seeman and L. Laurier and G. Ng and S. George and J. Torchia and H. V. Tol and H. Niznik},
  journal={Nature},
  year={1991},
  volume={350},
  pages={614-619}
}
DOPAMINE receptors belong to a superfamily of receptors that exert their biological effects through guanine nucleotide-binding (G) proteins. Two main dopamine receptor subtypes have been identified, D1 and D2, which differ in their pharmacological and biochemical characteristics. D1 stimulates adenylyl cyclase activity, whereas D2 inhibits it1–3. Both receptors are primary targets for drugs used to treat many psychomotor diseases, including Parkinson's disease and schizophrenia4,5. Whereas the… Expand
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This receptor has been characterized on the basis of three criteria: the deduced amino-acid sequence which reveals that it is a member of the family of G-protein-coupled receptors; the tissue distribution of the mRNA which parallels that of the D2 dopamine receptor; and the pharmacological profile of mouse fibroblast cells transfected with the cDNA. Expand
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The cloning of the D1 receptor gene is reported, which resides on an intronless region on the long arm of chromosome 5, near two other members of the G-linked receptor family, and binds drugs with affinities identical to the native human D1 receptors. Expand
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
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The cloning of a gene that encodes a dopamine receptor gene that has high homology to the human dopamine D2 and D3 receptor genes is reported, which suggests the existence of other types of dopamine receptors which are more sensitive to clozapine. Expand
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