Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine

@article{Tol1991CloningOT,
  title={Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine},
  author={Hubert H.M. Van Tol and James R. Bunzow and H C Guan and Roger K. Sunahara and Philip Seeman and Hyman B. Niznik and Olivier Civelli},
  journal={Nature},
  year={1991},
  volume={350},
  pages={610-614}
}
DOPAMINE receptors belong to the family of G protein-coupled receptors. On the basis of the homology between these receptors, three different dopamine receptors (D1,D2,D3) have been cloned1–7. Dopamine receptors are primary targets for drugs used in the treatment of psychomotor disorders such as Parkinson's disease and schizophrenia8,9. In the management of socially withdrawn and treatment-resistant schizophrenics, clozapine10 is one of the most favoured antipsychotics because it does not cause… 
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This is the first report of a receptor in the catecholamine receptor family that displays polymorphic variation in the human population and such variation among humans may underlie individual differences in susceptibility to neuropsychiatric disease and in responsiveness to antipsychotic medication.
The dopamine D4 receptor in schizophrenia: an update
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The overall D2 characteristics, plus the anomalous divergence from these characteristics, make the D4 receptor a highly attractive candidate for the dopamine receptor abnormality of schizophrenia.
Dopamine D4 receptors and development of newer antipsychotic drugs
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Polymorphisms of the dopamine D4 receptor and response to antipsychotic drugs
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The results of this study suggest that inherited variants of D4 may explain some of the interindividual variation seen in patient response to different classes of antipsychotic medication.
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