Cloning of the gamma chain of the human IL-2 receptor.

@article{Takeshita1992CloningOT,
  title={Cloning of the gamma chain of the human IL-2 receptor.},
  author={Tatsuya Takeshita and Hironobu Asao and Kiyoshi Ohtani and Norihisa Ishii and Satoru Kumaki and Nobuyuki Tanaka and Hiroshi Munakata and Morihiko Nakamura and Kazuo Sugamura},
  journal={Science},
  year={1992},
  volume={257 5068},
  pages={379-82}
}
A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The gamma chain is necessary for the formation of the high- and intermediate-affinity receptors, which consists of alpha beta gamma heterotrimers and beta gamma heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the gamma chain is present… CONTINUE READING

From This Paper

Topics from this paper.
130 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 130 extracted citations

Similar Papers

Loading similar papers…