Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.

@article{Coulouarn1998CloningOT,
  title={Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord.},
  author={Yolaine Coulouarn and Isabelle Lihrmann and Sylvie J{\'e}gou and Y Anouar and Herv{\'e} Tostivint and Jean Claude Beauvillain and J Michael Conlon and Howard A. Bern and Hubert Vaudry},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 26},
  pages={15803-8}
}
Urotensin II (UII) is a cyclic peptide initially isolated from the caudal neurosecretory system of teleost fish. Subsequently, UII has been characterized from a frog brain extract, indicating that a gene encoding a UII precursor is also present in the genome of a tetrapod. Here, we report the characterization of the cDNAs encoding frog and human UII precursors and the localization of the corresponding mRNAs. In both frog and human, the UII sequence is located at the C-terminal position of the… CONTINUE READING

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Coulouarn et al

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  • Proc. Natl. Acad. Sci. USA 95
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