Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease

@article{PaisnRuz2004CloningOT,
  title={Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease},
  author={Coro Pais{\'a}n-Ruı́z and Shushant Jain and E Evans and William P. Gilks and Javier Sim{\'o}n and Marcel P. van der Brug and A. L{\'o}pez de Munain and Silvia Aparicio and Angel Martı́nez Gil and Naheed Zia Khan and Janel O. Johnson and Javier Ruiz Martinez and David B. G. Nicholl and Itxaso Marti Carrera and Amets Sa{\'e}nz Peňa and Rohan de Silva and Andrew Lees and Jos{\'e} F{\'e}lix Martı́-Mass{\'o} and Jordi P{\'e}rez-Tur and Nick W. Wood and Andrew Singleton},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={595-600}
}
Parkinson's disease (PD; OMIM #168600) is the second most common neurodegenerative disorder in the Western world and presents as a progressive movement disorder. The hallmark pathological features of PD are loss of dopaminergic neurons from the substantia nigra and neuronal intracellular Lewy body inclusions. Parkinsonism is typically sporadic in nature; however, several rare familial forms are linked to genetic loci, and the identification of causal mutations has provided insight into the… CONTINUE READING