Cloning of rainbow trout SLC26A1: involvement in renal sulfate secretion.

  title={Cloning of rainbow trout SLC26A1: involvement in renal sulfate secretion.},
  author={Fumi Katoh and Martin Tresguerres and Kyung Mi Lee and Toyoji Kaneko and K Atsumi Aida and Greg G. Goss},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={290 5},
  • F. KatohM. Tresguerres G. Goss
  • Published 1 May 2006
  • Biology, Environmental Science
  • American journal of physiology. Regulatory, integrative and comparative physiology
The kidney plays an important role in ion regulation in both freshwater and seawater fish. However, ion transport mechanisms in the teleost kidney are poorly understood, especially at the molecular level. We have cloned a kidney-specific SLC26 sulfate/anion exchanger from rainbow trout (Oncorhynchus mykiss) that is homologous to the mammalian SLC26A1 (Sat-1). Excretion of excess plasma sulfate concentration after Na2SO4 injection corresponded to significantly higher expression of the cloned… 

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