Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.

@article{Takakura1999CloningOH,
  title={Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells.},
  author={Masahiro Takakura and Satoru Kyo and Taro Kanaya and Hirofumi Hirano and Jun Takeda and Masuo Yutsudo and Masaki Inoue},
  journal={Cancer research},
  year={1999},
  volume={59 3},
  pages={551-7}
}
Telomerase activation is thought to be a critical step in cellular immortalization and carcinogenesis. Of the three major subunits comprising human telomerase, human telomerase catalytic subunit (hTERT) has been shown to be a rate-limiting determinant of the enzymatic activity of human telomerase. However, little is known concerning how expression of hTERT is regulated in human cells. To identify the regulatory elements controlling hTERT gene expression, approximately 3.5 kb of the 5'-flanking… CONTINUE READING
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