Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus.

@article{Yasojima1997CloningOH,
  title={Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus.},
  author={K Yasojima and Atsushi Tsujimura and Takeshi Mizuno and Yasufumi Shigeyoshi and Johji Inazawa and Reiko F. Kikuno and Kanji Kuma and Katsutoshi Ohkubo and Yoshitaka Hosokawa and Yasuhiko Ibata and Takashi Abe and Toshio Miyata and Kenichi Matsubara and Koichi Nakajima and Tamotsu Hashimoto-Gotoh},
  journal={Biochemical and biophysical research communications},
  year={1997},
  volume={231 2},
  pages={481-7}
}
We identified a novel gene, kf-1, highly expressed in the normal cerebellum but not in the cerebral cortex, the expression of which could have been augmented in the cerebral cortex of a sporadic Alzheimer's disease patient. We cloned human and mouse entire kf-1 cDNAs encoding conserved 79 kDa proteins containing a zinc-binding RING-H2 finger motif at the carboxy-terminus as found in acetylcholine receptor-associated protein (RAPsyn). The 3'-untranslated regions are highly conserved between… CONTINUE READING

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