Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.

@article{Mistry2002CloningOH,
  title={Cloning of human agmatinase. An alternate path for polyamine synthesis induced in liver by hepatitis B virus.},
  author={Sanjay K Mistry and Tim J Burwell and Rebecca M Chambers and Laura A. Rudolph-Owen and Frank Spaltmann and Walter J Cook and Sidney M Morris},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2002},
  volume={282 2},
  pages={G375-81}
}
Agmatinase, which hydrolyzes agmatine to putrescine and urea, not only represents a potentially important mechanism for regulating the biological effects of agmatine in mammalian cells but also represents an alternative to ornithine decarboxylase for polyamine biosynthesis. We have isolated a full-length cDNA encoding human agmatinase whose function was confirmed by complementation in yeast. The single-copy human agmatinase gene located on chromosome 1 encodes a 352-residue protein with a… CONTINUE READING
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