Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
@article{Kinashi1986CloningOC, title={Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II}, author={T. Kinashi and N. Harada and E. Severinson and T. Tanabe and P. Sideras and M. Konishi and C. Azuma and A. Tominaga and S. Bergstedt-Lindqvist and M. Takahashi and F. Matsuda and Y. Yaoita and K. Takatsu and T. Honjo}, journal={Nature}, year={1986}, volume={324}, pages={70-73} }
Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells1,2. These soluble factors are functionally divided into two groups: B-cell growth factor (BCGF), thought to be involved in B-cell proliferation; and B-cell differentiation factor (BCDF), responsible for maturation of activated B cells into immunoglobulin-secreting cells3–6. This classification needs to be re-examined in the light of the recent cloning of… CONTINUE READING
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