Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

@article{Kinashi1986CloningOC,
  title={Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II},
  author={T. Kinashi and N. Harada and E. Severinson and T. Tanabe and P. Sideras and M. Konishi and C. Azuma and A. Tominaga and S. Bergstedt-Lindqvist and M. Takahashi and F. Matsuda and Y. Yaoita and K. Takatsu and T. Honjo},
  journal={Nature},
  year={1986},
  volume={324},
  pages={70-73}
}
  • T. Kinashi, N. Harada, +11 authors T. Honjo
  • Published 1986
  • Chemistry, Medicine
  • Nature
  • Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells1,2. These soluble factors are functionally divided into two groups: B-cell growth factor (BCGF), thought to be involved in B-cell proliferation; and B-cell differentiation factor (BCDF), responsible for maturation of activated B cells into immunoglobulin-secreting cells3–6. This classification needs to be re-examined in the light of the recent cloning of… CONTINUE READING
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