Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

@article{Kinashi1986CloningOC,
  title={Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II},
  author={Tatsuo Kinashi and Nobuyuki Harada and Eva Severinson and Toshizumi Tanabe and Paschalis Sideras and Mikio Konishi and Chihiro Azuma and Akira Tominaga and Susanne Bergstedt‐Lindqvist and Masazumi Takahashi and Fumihiko Matsuda and Yoshio Yaoita and Kiyoshi Takatsu and Tasuku Honjo},
  journal={Nature},
  year={1986},
  volume={324},
  pages={70-73}
}
Proliferation and maturation of antigen-stimulated B cells are regulated by several soluble factors derived from macrophages and T cells1,2. These soluble factors are functionally divided into two groups: B-cell growth factor (BCGF), thought to be involved in B-cell proliferation; and B-cell differentiation factor (BCDF), responsible for maturation of activated B cells into immunoglobulin-secreting cells3–6. This classification needs to be re-examined in the light of the recent cloning of… 
Role of recombinant interleukin-1 compared to recombinant T-cell replacing factor/interleukin-5 in B-cell differentiation.
TLDR
It is suggested that IL-1 acts primarily on resting B cells as a differentiation-inducing factor in the presence of antigen, and also acts as a 'priming' factor for TRF/IL-5 in 5-day cultures of B cells.
The biology of interleukin-6.
TLDR
Human IL-6 (BSF2) was originally identified as a factor in the culture supernatants of mitogen or antigen-stimulated peripheral mononuclear cells, which induced immunoglobulin production in Epstein Barr virus transformed B-cell lines or in Staphylococcus aureus Cowan 1 stimulated normal B cells.
Molecular Biology of Interleukin 4 and Interleukin 5 Genes and Biology of their Products that Stimulate B Cells, T Cells and Hemopoietic Cells
TLDR
A regulatory network formed between lymphoid cells and hemopoietic cells through the action of multiple lymphokines produced by activated T cells is revealed.
Revisiting the Identification and cDNA Cloning of T Cell-Replacing Factor/Interleukin-5
TLDR
The history of the initial discovery of T cell-replacing factor/B cell growth factor II that appeared to be involved in B cell growth and differentiation and the discovery and characterization of interleukin-5 are summarized.
Interleukin 2 and low molecular weight B cell growth factor are T cell‐replacing factors for different subpopulations of human B cells*
TLDR
Results show that high‐density B cells can in fact respond to TRF, and that IL2 and BCGFlow, act on different populations of B cells which may be defined by prior exposure to T cells.
B-Cell Growth and Differentiation Factors
  • K. Takatsu
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1988
TLDR
Evidence is provided that helper T cells recognize antigen in the context of class I1 major histocompatibility complex (MHC) molecules on accessory cells and/or B cells, and there is clear that the above two models represent two different mechanisms.
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TLDR
The addition of appropriate amounts of N-acetylgalactosamine in the assay systems for TRF preferentially induced a profound suppression for TRf-mediated PFC responses, indicating that B151-TRF is a glycosylated glycoprotein containing N- acetylgalactsosamine residues.
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TLDR
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TLDR
This paper reports that a mouse lymphokine that stimulates the production of functional eosinophils in liquid bone marrow cultures appears to be identical to the B-cell growth factor II described by Swain and Dutton, and proposes the name "interleukin 4" for this molecule, suggesting the defining property should be its eOSinophil-differentiating activity.
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New T cell lines secreting IgG1 induction factor are developed by cloning mixed lymphocyte culture populations and the assay is quantitative, reproducible and accurate, both when induction of IgGl as well as reduction of IgG3 and IgG2b were measured.
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