Cloning of cDNAs for Fanconi's anaemia by functional complementation

@article{Strathdee1992CloningOC,
  title={Cloning of cDNAs for Fanconi's anaemia by functional complementation},
  author={Craig A. Strathdee and Hanna Gavish and William R. Shannon and Manuel Buchwald},
  journal={Nature},
  year={1992},
  volume={356},
  pages={763-767}
}
Fanconi's anaemia is a rare autosomal recessive disorder characterized by progressive pan-cytopaenia and a cellular hypersensitivity to DNA crosslinking agents. Four genetic complementation groups have been identified so far, and here we use a functional complementation method to clone complementary DNAs that correct the defect of group C cells. The cDNAs encode alternatively processed transcripts of a new gene, designated FACC, which is mutated in group C patients. The predicted FACC… 
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TLDR
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TLDR
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