Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

@article{Tsai1989CloningOC,
  title={Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells},
  author={Shih-Feng Tsai and David I. K. Martin and Leonard I. Zon and Alan D D'Andrea and Gordon G. Wong and Stuart H Orkin},
  journal={Nature},
  year={1989},
  volume={339},
  pages={446-451}
}
Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man. 
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