Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

@article{Noma1986CloningOC,
  title={Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter},
  author={Yoshihiko Noma and Paschalis Sideras and Takayuki Naito and Susanne Bergstedt-Lindquist and Chihiro Azuma and Eva Severinson and Toshizumi Tanabe and Tatsuo Kinashi and Fumihiko Matsuda and Yoshio Yaoita and Tasuku Honjo},
  journal={Nature},
  year={1986},
  volume={319},
  pages={640-646}
}
Complementary DNA encoding the IgG1 induction factor, the first lymphokine directed to B lymphocytes, from a murine T-cell line has been cloned using a new strategy. The putative primary amino-acid sequence was deduced from the nucleotide sequence determined. The lymphokine synthesized by the direction of this cloned cDNA has many other functions, such as production of B-cell growth factor-1 and induction of Ia on B cells. 
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Rec recombinant IL4 activated the murine T cell line CTLL to increased DNA synthesis but not to growth but also activated normal concanavalin A (Con A)‐stimulated T cells both to increasedDNA synthesis and to growth.
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The history of the initial discovery of T cell-replacing factor/B cell growth factor II that appeared to be involved in B cell growth and differentiation and the discovery and characterization of interleukin-5 are summarized.
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Lymphotoxin is an important T cell-derived growth factor for human B cells.
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Recombinant lymphotoxin enhanced the proliferation of activated B cells and augmented B cell proliferation and immunoglobulin secretion induced by interleukin-2.
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