Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A.

@article{Sugawara2000CloningOA,
  title={Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A.},
  author={Mitsuru Sugawara and Takeo Nakanishi and You-jun Fei and Wei Huang and Malliga E. Ganapathy and Frederick H. Leibach and Vadivel Ganapathy},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 22},
  pages={16473-7}
}
We report here on the cloning and functional characterization of the protein responsible for the system A amino acid transport activity that is known to be expressed in most mammalian tissues. This transporter, designated ATA2 for amino acid transporter A2, was cloned from rat skeletal muscle. It is distinct from the neuron-specific glutamine transporter (GlnT/ATA1). Rat ATA2 consists of 504 amino acids and bears significant homology to GlnT/ATA1 and system N (SN1). ATA2-specific mRNA is… CONTINUE READING
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