Cloning of a novel phospholipase C-delta isoform from pacific purple sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early embryonic development.

@article{Coward2004CloningOA,
  title={Cloning of a novel phospholipase C-delta isoform from pacific purple sea urchin (Strongylocentrotus purpuratus) gametes and its expression during early embryonic development.},
  author={Kevin Coward and Helen E. Owen and Albert J. Poustka and Olivia C Hibbitt and Richard Tunwell and Hiroki Kubota and Karl Swann and John Parrington},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={313 4},
  pages={894-901}
}
Calcium (Ca(2+)) is a ubiquitous intracellular messenger, controlling a diverse range of cellular processes, including fertilization and development of the embryo. One of the key mechanisms involved in triggering intracellular calcium release is the generation of the second messenger inositol-1,4,5-phosphate (IP(3)) by the phospholipase C (PLC) class of enzymes. Although five distinct forms of PLC have been identified in mammals (beta, gamma, delta, epsilon, and zeta), only one, PLCgamma, has… CONTINUE READING