Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA.

@article{Blesch1994CloningOA,
  title={Cloning of a novel malignant melanoma-derived growth-regulatory protein, MIA.},
  author={Armin Blesch and Anja Katrin Bosserhoff and Rainer Apfel and C Behl and B Hessdoerfer and Anna Schmitt and Piotr Jachimczak and Friedrich Lottspeich and Ralf Buettner and Ullrich Bogdahn},
  journal={Cancer research},
  year={1994},
  volume={54 21},
  pages={5695-701}
}
Growth and progression of malignant melanoma cells is influenced by a complex network of growth-stimulating and -inhibiting factors produced by both the tumor cells and the local environment. Here we report the purification and molecular cloning of a novel growth regulating protein, designated melanoma inhibitory activity (MIA) and provide a preliminary functional characterization. MIA is translated as a 131-amino acid precursor and processed into a mature 107-amino acid protein after cleavage… CONTINUE READING

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