Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation.

  title={Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation.},
  author={Naoko Matsuo and Seishi Ogawa and Yuji Imai and Tomoko Takagi and Masaya Tohyama and David M. Stern and Akio Wanaka},
  journal={The Journal of biological chemistry},
  volume={270 47},
Astrocytes have a critical role in the neuronal response to ischemia, as their production of neurotrophic mediators can favorably impact on the extreme sensitivity of nervous tissue to oxygen deprivation. Using a differential display method, a novel putative RNA binding protein, RA301, was cloned from reoxygenated astrocytes. Analysis of the deduced amino acid sequence showed two ribonucleoprotein domains and serine/arginine-rich domains, suggestive of their function as RNA splicing factor… CONTINUE READING


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